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Characteristics, functions, and applications of metallothionein in aquatic vertebrates

Frontiers
Figure 1. Metallothioneins have four main functions in aquatic vertebrate. They are respectively bioaccumulation of toxic metals and detoxification, homeostatic...
قبل 6 أشهر

Centenarian hippocampus displays high levels of astrocytic metallothioneins - Saenz‐Antoñanzas - 2024 - Aging Cell

Wiley Online Library
These results indicate that the expression of MTs specifically in astrocytes is a mechanism for protection during aging.
قبل 7 أشهر

Integrative Analysis of Metallothioneins Identifies MT1H as Candidate Prognostic Biomarker in Hepatocellular Carcinoma

Frontiers
The present study attempted to visualize the prognostic landscape of MT functional isoforms and identify potential prognostic biomarkers in hepatocellular...
قبل 6 أشهر

A case-control study of Metallothionein-1 expression in breast cancer and breast fibroadenoma

Nature
Studies suggest that overexpression of metallothionein is associated with more aggressive breast tumors and more advanced-stage disease.
قبل 68 شهرًا

Metallothionein 1: A New Spotlight on Inflammatory Diseases

Frontiers
Mounting evidence suggests that MT1 has a broader role in inflammatory diseases and can shape innate and adaptive immunity.
قبل 11 شهرًا

A de novo evolved domain improves the cadmium detoxification capacity of limpet metallothioneins

Nature
Metallothioneins (MTs) constitute an important family of metal binding proteins. Mollusk MTs, in particular, have been used as model systems...
قبل 19 شهرًا

The role of metallothionein in a dinitrofluorobenzene-induced atopic dermatitis-like murine model

Nature
These results suggest that MT may play a protective role against AD development, and that antioxidant and nuclear protective mechanisms may be involved.
قبل 77 شهرًا

Microalgal Metallothioneins and Phytochelatins and Their Potential Use in Bioremediation

Frontiers
The present review reports the current knowledge on microalgal MTs and PCs and describes the state of art of their use for HM bioremediation.
قبل 11 شهرًا

Prolongation of metallothionein induction combats Aß and α-synuclein toxicity in aged transgenic Caenorhabditis elegans

Nature
We report here that metallothionein (MT), an endogenous metal detoxifying protein, is increased in young amyloid ß (Aß) expressing Caenorhabditis elegans.
قبل 54 شهرًا

AP-1 (bZIP) Transcription Factors as Potential Regulators of Metallothionein Gene Expression in Tetrahymena thermophila

Frontiers
In this research work, we characterize four AP-1 transcription factors in each of four different analyzed Tetrahymena species, detecting a high conservation...
قبل 11 شهرًا